Upper Airway Microbiome Offers Clues For Future Asthma Treatments

January 9, 2020

Lisa Feierstein

Asthma, Breathe EZ, Children's Health

Your Microbiome – Good and Bad Bacteria

Scientists classify bacteria as either beneficial or pathogenic.

You may be familiar with beneficial bacteria found in fermented foods like yogurt that help us digest our food, absorb nutrients and maintain a healthy digestive system. Most of us have been exposed to pathogenic bacteria like the ones that cause strep throat (Streptococcus), pneumonia (Streptococcus pneumoniae) and food poisoning (Escherichia coli and Salmonella).

Study Details

The Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations (STICS) was conducted at the Washington University School of Medicine in St Louis and funded by the National Institutes of Health (NIH).

While the study was seeking to investigate the effectiveness of significantly higher doses of inhaled corticosteroids at the first sign of an asthma attack, the review of the nasal mucous samples revealed a distinct difference in the bacteria profile of the study participant’s upper respiratory biome between control and asthma flare up.

The study found no benefit to the larger doses of medication at the start of an asthma attack.

Study participants included 214 children with mild to moderate asthma that were currently treating their asthma symptoms and flare-ups with inhaled corticosteroids.

Curious Results

Nasal samples were collected from study participants twice. First when their asthma was under control, and when the participants had the signs of an emerging flare-up – known as the “yellow zone”.

The study data revealed that a rapid change occurred in the airway microbiome of study participants as they transitioned from respiratory health to disease.

Asthma in control: Microbiome dominated by beneficial bacteria

Yellow Zone: Microbiome contained bacteria associated with diseases like pneumonia and strep throat – Staphylococcus and Streptococcus.

Future Research Opportunities

This study showed a link between the bacteria and asthma symptoms but did not prove cause and effect.

Future study of the upper respiratory microbiome will help asthma researchers in their development of new asthma treatments. These new treatments might target the bacteria present in the upper respiratory microbiome in hopes of preventing asthma symptom flare ups.

Additional Resources

Study Information – Washington University School of Medicine
The Human Microbiome
Wearable Asthma Informatics: Future of Asthma Care in Children
Hidden Spots for Germs: Home, Office and Doctors Office

Puppies Reduce a Child’s Risk for Asthma

August 11, 2016

Lisa Feierstein

Allergies, Asthma, Breathe EZ, Children's Health

Asthma Triggers, Pets, research

The benefits of having a canine companion to come home to are numerous. New research states that lowering a child’s asthma risk is yet another reason to add to that list. Having a dog has been shown to reduce a child’s risk for asthma. It can also reduce levels of stress and depression, increase one’s physical shape, and enhance social skills.

A recent Swedish asthma study included more than one million children. Those with dogs in the home within the infant’s first year of life had a 15% lower rate of asthma.

Researchers say that their findings indicate that having a dog in the house may affect their child’s microbiome. Each individual’s inner bacterial environment of the gut is influenced by the food we consume and the air we breathe. Examinations are being made into whether there is a specific strain of bacteria that lessens the likelihood of asthma that is transmitted from dog to child.

Pets like Puppies = More time Outdoors

It is also worth noting that children living in households with dogs almost certainly spend more time outdoors and exercising more frequently. Both of these factors lower a child’s probability of developing asthma.

Interestingly enough, researchers have also explored data relating to children who grew up on farms. These children were exposed to farm animals such as cows, sheep, or horses. Findings show that these farm children had a 25% lower risk for an asthma diagnosis than those who did not grow up on a farm.

While these discoveries are not enough to definitively prove that puppies prevent asthma, they absolutely suggest that it isn’t necessary to rehome family pets for fear of their children developing respiratory problems by being around dogs.

Tove Fall, a coordinator of the study and assistant professor at Uppsala University in Sweden, stated, “It might be due to a single factor or more likely, a combination of several factors related to dog ownership lifestyle or dog owner’s attitudes, such as kids’ exposure to household dirt and pet dust, time spent outdoors or being physically active.”

All I’m hearing is a scientific reason for parents to give in and give their children a puppy!